Liver transplant (2024)

A liver transplant is an operation to remove your liver and replace it with a healthy one from a donor.

It may be recommended if your liver has stopped working properly (liver failure) and other treatments cannot help.

What happens

Having a liver transplant involves 3 main stages:

  1. Having an assessment – to find out if you're suitable for a liver transplant, you'll have several tests and will be asked about your health and lifestyle.
  2. Going on the waiting list – if you're suitable for a transplant, you'll need to wait for a healthy donor liver to become available, which could take several months or more.
  3. Having the operation – when a liver is available, you'll go into hospital for surgery to remove your damaged liver and replace it with the healthy donor one.

This can be a long and difficult process, both physically and emotionally.

Life afterwards

Liver transplants are generally very successful and most people are eventually able to return to their normal activities afterwards.

It can take a year or more to fully recover.

After a liver transplant, you'll need to:

  • take medicines to stop your body attacking the new liver (immunosuppressants) for the rest of your life
  • have regular check-ups to see how you're doing and check how well your new liver is working
  • stay as healthy as possible – including eating healthily and exercising regularly

Most people live more than 10 years after a liver transplant and many live for up to 20 years or more.

Read more about life after a liver transplant

Risks and complications

A liver transplant is a big operation that has a risk of some serious complications. These can happen during, soon after, or even years afterwards.

Some of the main complications and risks of a liver transplant are:

  • your body attacking the new liver (rejection)
  • the new liver not working properly (graft failure)
  • a blockage or leak in one of your bile ducts – bile is a liquid produced inside the liver that passes out through small tubes called bile ducts
  • side effects of the immunosuppressant medicine – such as an increased risk of infections and kidney problems

A liver transplant will only be recommended if the risks of not having a transplant outweigh the risks of having one.

Liver donation

If you wish to donate your liver, there are 2 ways you can do this:

  • donate your liver after you die. You do not have to register for organ donation in most parts of the UK. If you do not want to donate after you die, you can register your choice. Read more about registering for organ donation
  • become a living donor – you have an operation to remove part of your liver and give it to someone who needs a transplant (usually a family member or friend)

Page last reviewed: 29 January 2021
Next review due: 29 January 2024

Liver transplant (2024)

FAQs

What percentage of liver transplants are successful? ›

Liver transplant survival rates

In general, about 75% of people who undergo liver transplant live for at least five years. That means that for every 100 people who receive a liver transplant for any reason, about 75 will live for five years and 25 will die within five years.

What is the average life expectancy after a liver transplant? ›

On average, most people who receive LT live for more than 10 years. Many may live for up to 20 years or more after the transplant. A study says 90% of people with transplant survive for at least 1 year, and 70% of people may live for at least 5 years after transplant.

Why don't liver transplants work? ›

Complications of a liver transplant can include rejection, an increased risk of infection, graft failure, biliary conditions and a higher risk of developing certain conditions – including some types of cancer.

What are the odds of liver transplant rejection? ›

Rejection happens in up to 30 in 100 patients. The risk of rejection is highest in the first 6 months after a transplant. After this time, your body's immune system is less likely to recognise the liver as coming from another person. Chronic rejection happens in 2 in 100 patients.

How many people live 20 years after liver transplant? ›

72 percent still alive 5 years after the surgery. 53 percent still alive 20 years after the surgery.

What is the most common cause of death after liver transplant? ›

Deaths from cirrhosis and liver failure accounted for a high proportion of deaths within 1 year after transplantation, and deaths from malignant tumors such as hepatocellular carcinoma were high among late-stage deaths.

What disqualifies you from a liver transplant? ›

Common reasons why a liver transplant may not be the right treatment for you include: You are too ill or frail to cope with the surgery and aftercare. You have recently had cancer, a serious infection, a heart attack or a stroke. You may struggle taking the immunosuppressant medicines after a liver transplant.

What is the longest liver transplant survivor? ›

World's Longest Surviving Liver-Pancreas Recipient
  • Albert M. Harary. 1New York University School of Medicine and Lenox Hill Hospital, New York, NY. ...
  • Kareem Abu-Elmagd. 2Thomas E. ...
  • Ngoc Thai. 2Thomas E. ...
  • Ron Shapiro. 2Thomas E. ...
  • Satoru Todo. 2Thomas E. ...
  • John J. Fung. ...
  • Thomas E. Starzl.

Can you live a full life after liver transplant? ›

Liver transplant can have excellent outcomes. Recipients have been known to live a normal life over 30 years after the operation.

Who gets priority for liver transplant? ›

If your MELD or PELD score is very high, you will have very high priority for a transplant. MELD scores range from 6 (least sick) to 40 (most sick). PELD scores may range lower or higher than MELD scores. Your score may go up or down over time as your liver disease either worsens or improves.

What state is easiest to get a liver transplant? ›

Florida may have the shortest waiting list as they have the highest transplant rates from deceased donors. Waiting times can depend on factors such as liver health, overall health, age, location, blood type, and body size.

Can liver transplant cure cirrhosis? ›

Prolonged Life Expectancy: Liver transplantation significantly improves survival rates for individuals with advanced cirrhosis compared to alternative treatments. Studies have shown that liver transplant surgery recipients have a five-year survival rate of approximately 80% and a ten-year survival rate of 60-70%.

At what age will they not do a liver transplant? ›

Is there an age limit for liver transplantation? The age limit is individualized as it varies with a patient's overall health condition. However, it is rare to offer liver transplant to someone greater than 70 years old.

What is the most rejected organ transplant? ›

Chronic rejection has widely varied effects on different organs. At 5 years post-transplant, 80% of lung transplants, 60% of heart transplants and 50% of kidney transplants are affected, while liver transplants are only affected 10% of the time.

Can your body reject a liver transplant years later? ›

Chronic rejection happens in 2 in 100 patients. The risk of rejection is highest in the 6 months after a transplant. After this time, your body's immune system is less likely to recognise the liver as coming from another person. However, chronic rejection can occur after 6 months.

Is a liver transplant high risk? ›

After liver transplant, the risk of skin cancer is around 40 in 100 patients over a lifetime. The risk of post-transplant lymphoproliferative disease (PTLD), a type of white blood cell cancer, is around 2 to 4 in 100. Symptoms of PTLD include night-sweats, fevers and weight loss.

How hard is it to recover from a liver transplant? ›

Most patients can return to a normal or near-normal activity and participate in fairly vigorous exercise six to 12 months after successful liver transplant surgery. Often, we let patients return to work and drive as little as two to three months after liver transplantation.

How much risky is liver transplant? ›

Infections and bile duct complications are common after a liver transplant. You will need to take strong medicines to suppress your immune system. You may need further surgery to fix any problems. It is possible that the transplanted liver doesn't work properly.

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