Glycolysisis the first step in the breakdown of glucose to extract energy for cellular metabolism. Glycolysis consists of an energy-requiring phase followed by an energy-releasing phase.
Log in Ahmad Nawaz 9 years agoPosted 9 years ago. Direct link to Ahmad Nawaz's post “Why the 1st phase are sam...” Why the 1st phase are same in aerobic and anaerobic respiration • (4 votes) Yeongseo Lee 9 years agoPosted 9 years ago. Direct link to Yeongseo Lee's post “This is because oxidation...” This is because oxidation in glycolysis doesn't involve oxygen atoms. It's just movement of hydrogen. So it's behaving in the same way with or without oxygen. (83 votes) 유상기 8 years agoPosted 8 years ago. Direct link to 유상기's post “when NAD is turned into N...” when NAD is turned into NADH, G3P(5H) loses two electrons and "two" protons. but in the next step, 3-bis..., theres still 4H. not sure how this happens. • (16 votes) Amethyst 8 years agoPosted 8 years ago. Direct link to Amethyst's post “The other H comes from HP...” The other H comes from HPO4 with a 2- charge which eventually turns itself into inorganic phosphate. (12 votes) Stephen Hutchinson 9 years agoPosted 9 years ago. Direct link to Stephen Hutchinson's post “In the Investment phase, ...” In the Investment phase, where did the 2 atps come from that were used up? was it taken from somewhere else? if the goal is to produce atp in glycilysis, where do we get atp to begin the process? • (7 votes) Nicholas Cook-Rostie 9 years agoPosted 9 years ago. Direct link to Nicholas Cook-Rostie's post “The ATPs originally came ...” The ATPs originally came from your mother through parental nutrition, while you where developing in the womb. When you are born you will have a stock pile of ATP in your body, which must be replenished to stay alive. The body has many ways to make ATP, which can be seen by looking at the vast amount of metabolic reactions that occur with the body. This is also why we can survive for a long time without any additional consumption of food as the many catabolism pathways in the body that breakdown larger molecules and transfer the energy from the breakdown to ATP. When food is abundant the breakdown of glucose by glycolysis and the Krebs cycle will produce much more ATP than the 2 ATPS required in the investment phase. Additionally, this investment phase aids in regulating the metabolic reactions that occur in our body/cells. (26 votes) Syasya Jee 9 years agoPosted 9 years ago. Direct link to Syasya Jee's post “In the highlight glycolys...” In the highlight glycolysis part,in the second last paragraph,why fructose-1,6-bisphosphate is unstable? • (4 votes) Nicholas Cook-Rostie 9 years agoPosted 9 years ago. Direct link to Nicholas Cook-Rostie's post “One important note is tha...” One important note is that the enzyme that catalyzes the reaction phosphofructosekinase is what actually speeds up or slow downs glycolysis. Once fructose-1,6-bisphosphate is formed it will be broken down to the two carbon molecules at the same speed. The way it is speed up or slowed down is due to phosphofructosekinase the enzyme that catalyzes the reaction to create fructose-1,6-bisphosphate is regulated by both ATP and ADP, when ATP levels are high it is inhibited and less fructose-1,6-bisphosphate will be created when ADP levels are high it will be activated and more fructose-1,6-bisphosphate will be created. This allows the cells a way to regulate the breakdown of glucose depending on the energy needs of the cell as stated by Chris. (10 votes) chocolateaddictedartist a year agoPosted a year ago. Direct link to chocolateaddictedartist's post “In step 6, where does the...” In step 6, where does the second phosphate group come from? • (6 votes) 45496 a year agoPosted a year ago. Direct link to 45496's post “By my understanding, phos...” By my understanding, phosphates are often freely floating throughout the cell. This is because they're used for tons of processes, and enzymes like phosphatase clip them off of ATP and various other molecules during reactions, and then just leave them to float around. (2 votes) wardatajammal 8 years agoPosted 8 years ago. Direct link to wardatajammal's post “what is the difference be...” what is the difference between aerobic and anaerobic glycolysis? • (2 votes) Emily 8 years agoPosted 8 years ago. Direct link to Emily's post “Aerobic is within an oxyg...” Aerobic is within an oxygen filled environment. and anaerobic there is no oxygen present in the environment. (7 votes) farha.elgammal 9 years agoPosted 9 years ago. Direct link to farha.elgammal's post “in step 6 in the detailed...” in step 6 in the detailed payoff phase... how after NAD+ is reduced, gained 2 H+ and converted to NADH, H+ is still produced ? • (4 votes) Matt B 9 years agoPosted 9 years ago. Direct link to Matt B's post “I think you have two very...” I think you have two very subtle differences mixed. Note that one H radical is [H]+ with one electron, and the reason why I write this is because when you add the proton, the H+, then you actually also need to add additional electrons, so for every one H you also have one electron. You would write: (6 votes) diamonnrose 8 years agoPosted 8 years ago. Direct link to diamonnrose's post “What is unusual about fru...” What is unusual about fructose being metabolized in the liver vs other tissue types? • (3 votes) Revan Rangotis 8 years agoPosted 8 years ago. Direct link to Revan Rangotis's post “There are several reasons...” There are several reasons. Simply put, the liver is really well equipped and prepared to metabolise it and also fructose, as opposed to glucose for example, seems to be a better substrate for glycogen synthesis in the liver. (3 votes) saud alsadoan The steps 5&6 are confusing me without structures please. • (3 votes) Devansh Shah 8 years agoPosted 8 years ago. Direct link to Devansh Shah's post “DHAP gets converted to G3...” DHAP gets converted to G3P (glyceraldehyde-3-phosphate) by the enzyme triosephosphate isomerase and then you get 2 G3P molecules which get converted to 1, 3 bisphosphoglycerate by glyceraldahyde-3-phosphate dehydrogenase and at the same time you have 2 NAD+ being reduced to 2 NADH by a hydrogen ion and 2e- going to each NAD+ (3 votes) Caroline 5 years agoPosted 5 years ago. Direct link to Caroline's post “Is this substrate-level p...” Is this substrate-level phosphorylation? • (3 votes) Ivana - Science trainee 5 years agoPosted 5 years ago. Direct link to Ivana - Science trainee's post “True. Substrate level pho...” True. Substrate level phosphorylation (physical addition of phosphate to the ADP and building ATP) can happen during glycolysis and TCA in the matrix of mitochondria. This paper contrasts substrate phosphorylation and oxidative phosphorylation: (1 vote)Want to join the conversation?
Can you explained more detail on what is means by speeds up or slows down glycolysis?I still dont understand.
Thank you.
Thanks in advance.
1. The NAD+ gains 2H (free radical) to become NADH (free radical) & [H]+.
2. Alternatively, you could say that the NAD gains 2H (free radical) to give NADH2 (free radical)
Fructose and glucose both seem to be very similar, they have almost identical structures but even a tiny change in a molecule can affect how it is metabolised in the body. I recommend reading up on it further since that's a fascinating question worth exploring.
In step 4 the aldolase enzyme break up the "Fructose-1,6-phosphate" into GAP & DHAP
What's after that ?
https://www.researchgate.net/publication/320582985_Difference_Between_Substrate_Level_Phosphorylation_and_Oxidative_Phosphorylation
