Is Immunocompromised the Same as Immunosuppressed? (2024)

  • Definition
    • What Is Immunocompromised or Immunosuppressed?
  • Causes
    • What Causes Immunosuppression?
  • Treatment
    • What Is the Treatment for Immune Deficiency?
  • Guide

What Is Immunocompromised or Immunosuppressed?

Immunocompromised and immunosuppressed both refer to deficiencies in the immune system’s functioning. When one’s immune system does not work properly, the body’s ability to fight off infections or cancer is reduced.

What Causes Immunosuppression?

Secondary immune deficiency is the most common cause of immunosuppression. Secondary causes of immunosuppression refer to external factors that weaken a person’s immune system, such as:

  • Medications
  • Glucocorticoids
  • Immunomodulatory drugs
  • Calcineurin inhibitors
  • Chemotherapy drugs
  • Surgery
  • Removal of the spleen (splenectomy)
  • Bone marrow transplantation
  • Trauma/injury
  • Extreme environmental conditions
  • Ultraviolet (UV) light
  • Radiation
  • Low oxygen
  • Space flight
  • Metabolic diseases
  • Diabetes
  • Chronic uremia
  • Chronic infections
  • Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS)
  • Age extremes
  • Premature babies
  • Elderly adults
  • Malnutrition
  • Sickle cell anemia
  • Certain cancers
  • Multiple myeloma
  • Chronic lymphoid leukemia

Primary immune deficiencies are caused by genetic disorders, such as:

  • Down’s syndrome (trisomy 21)
  • Severe combined immune deficiency (SCID)
  • Common variable immune deficiency (CVID)
  • X-linked agammaglobulinemia

What Is the Treatment for Immune Deficiency?

Treatment for a person who is immunocompromised/immunosuppressed depends on the condition that is causing the weakened immune system.

If an infection is causing an immunodeficiency, it may be treated with:

Treatments for immunocompromised/immunosuppressed patients that are aimed at boosting the immune system include:

  • Immune globulin replacement therapy
  • Specialized immune globulins

Other treatments for immunocompromised/immunosuppressed patients include:

  • Hematopoietic cell transplant
  • Gene therapy
  • Enzyme replacement therapy
  • Biologics

References

Medscape Medical Reference

Is Immunocompromised the Same as Immunosuppressed? (2024)

FAQs

What is the difference between being immunosuppressed and immunocompromised? ›

You can become immunocompromised in one of these two ways: Immunosuppression is when your immune system is weakened with medications, like after an organ transplant. Immunodeficiency is when your body can't make enough of certain blood cells to defend itself against infection.

What is the difference between immunodeficiency and immunosuppression? ›

Inherited combined immunodeficiency affects both T cells and B cells. It may be deadly within the first year of life if it isn't treated early. People are said to be immunosuppressed when they have an immunodeficiency disorder due to medicines that weaken the immune system.

What's another word for immunocompromised? ›

A few examples: immunocompromised, immunosuppressed, primary immunodeficiency, secondary (or acquired) immunodeficiency, inborn errors of immunity.

Am I immunocompromised if I take immunosuppressants? ›

Your immune system protects you from intruders like bacteria, viruses or cancer. If you're taking immunosuppressants, it means your immune system won't work as well as it should to get rid of harmful invaders. Your provider may call this being immunocompromised.

Who is classified as immunosuppressed? ›

People who are immunosuppressed have a reduced ability to fight infections and other diseases. This may be caused by certain diseases or conditions, such as AIDS, cancer, diabetes, malnutrition, and certain genetic disorders.

Is being immunocompromised bad? ›

The immunocompromised shoulder a disproportionate burden

Many who are immunocompromised often have a diminished immune response to COVID-19 vaccination, and therefore remain at higher risk for severe COVID-19, hospitalisation and death than the general population.

What conditions qualify as immunocompromised? ›

Immunocompromised condition or weakened immune system

This includes people who have cancer and are on chemotherapy, or who have had a solid organ transplant, like a kidney transplant or heart transplant, and are taking medication to keep their transplant.

What is immunosuppression also known as? ›

Immunosuppression, also known as immune suppression or immunocompromise, means the immune system isn't working as well as it normally would. This includes any or all of the defences that make up the immune system - particularly the white cells in the bloodstream, the spleen and the lymph nodes.

How do you classify immunosuppression? ›

Immunosuppressive drugs or immunosuppressant are mainly categorized into four major classes' i.e., Glucocorticoids, Protein drugs, Intravenous gamma globulin and Protease inhibiter. Each class is further classified into subclasses.

What should immunocompromised patients avoid? ›

Avoid raw or rare meat and fish and uncooked or undercooked eggs. Cook meat until it's well-done. Thoroughly cook eggs (no runny yolks) and avoid foods containing raw eggs such as raw cookie dough or homemade mayonnaise. Avoid unpasteurized beverages, such as fruit juice, milk and raw milk yogurt.

What do you call a person with low immunity to disease? ›

But when you're immunocompromised, your immune system's defenses are low, affecting its ability to fight off infections and diseases.

How do you tell if you have a weakened immune system? ›

Symptoms
  1. Frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections.
  2. Inflammation and infection of internal organs.
  3. Blood disorders, such as low platelet count or anemia.
  4. Digestive problems, such as cramping, loss of appetite, nausea and diarrhea.

What is the difference between immunocompromised and immunodeficiency? ›

When your immune system fails to respond adequately to infection, it's called an immunodeficiency, and you may be immunocompromised. People may also suffer from the opposite condition, an overactive immune system that attacks healthy cells as though they were foreign bodies, and that is called an autoimmune response.

What is the most common immunosuppressant drug? ›

The most commonly used immunosuppressants include:
  • Prednisone.
  • Tacrolimus (Prograf)
  • Cyclosporine (Neoral)
  • Mycophenolate Mofetil (CellCept)
  • Imuran (Azathioprine)
  • Rapamune (Rapamycin, Sirolimus)

Can immunocompromised drink untreated water? ›

If you have a weak immune system, you should not drink water from surface sources or groundwater at risk of containing pathogens, unless the water has been treated to remove or inactivate at least 99.9 per cent of parasites (protozoa), 99.99 per cent of viruses and all harmful bacteria.

What qualifies someone as immunocompromised? ›

Immunocompromised condition or weakened immune system

This includes people who have cancer and are on chemotherapy, or who have had a solid organ transplant, like a kidney transplant or heart transplant, and are taking medication to keep their transplant.

What does "suppressed immune system" mean? ›

A suppressed immune system is weakened to the point that it cannot mount a proper immune response to protect the body from pathogens, such as bacteria, viruses, and other infectious microorganisms. Therefore, people with a suppressed immune system become vulnerable to various infectious diseases.

What does immunosuppression mean? ›

(IH-myoo-noh-suh-PREH-shun) Suppression of the body's immune system and its ability to fight infections and other diseases. Immunosuppression may be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation, to prevent rejection of the donor tissue.

What are the immunocompromised patients? ›

Think of your immune system as a strong army. Its mission? To protect you from enemies both foreign (viruses and bacteria) and domestic (diseases like cancer). But when you're immunocompromised, your immune system's defenses are low, affecting its ability to fight off infections and diseases.

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