How the ADHD Brain Biologically Differs From the Non-ADHD Brain (2024)

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder. This means there are differences in the ADHD brain that affect a child’s development. ADHD does not influence intelligence. It does, however, affect a person's ability to regulate attention and emotions, and it results in hyperactivity and impulsivity as well as organization problems.

Differences in the ADHD Brain

ADHD is a condition that comes under a lot of scrutiny. Naysayers question if it is real or say it is caused by lack of motivation, willpower, or bad parenting—none of which is true. However, if you or your child has ADHD, you can feel vulnerable to these comments.

Knowing that there are biological differences in the ADHD brain—compared to the brain of a person who does not have ADHD—can be validating for someone dealing with the condition, as it provides additional evidence of the realities of ADHD.

The differences can be divided into three areas: structure, function, and chemistry.

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Brain Structure

For many years, research showed there were clear structural differences in the ADHD brain.The largest review ever of ADHD patient brain scans was carried out at Radboud University Nijmegen Medical Centre and published in 2018.

Researchers reported that people with ADHD had smaller brain volume in five subcortical areas, and their total brain size was smaller, too. These differences were greater in children and less in adults.

Parts of the ADHD brain mature at a slower pace (approximately one to three years) and never reach the maturity of a person who does not have ADHD.

Anotherinteresting finding was that the amygdala and hippocampus are smaller in the brains of people with ADHD. These areas are responsible for emotional processing andimpulsivity and had previously not been definitively connected to ADHD.

What Is Impulsivity?

Brain Function

There are several types of brain imaging techniques that allow researchers to study how the ADHD brain operates and functions. These include:

  • Functional magnetic resonance imaging (fMRI)
  • Positron emission tomography (PET)
  • Single-photon emission computer tomography (SPECT)

There are alterations in blood flow to various areasof the brains in people with ADHD compared to people who do not have ADHD, including decreased blood flow to certain prefrontal areas.Decreased blood flow indicates decreased brain activity.

The prefrontal area of the brain houses the executive functions and they are responsible for many tasks including planning, organizing, paying attention, remembering, and emotional reactions.

Evidence also suggests that ADHD may be related to dysfunctional brain connectivity. Research using resting-state MRIs suggests that individuals with ADHD may have increased functional connectivity in certain regions of the brain.

One study published in 2010 found that children with ADHD do not have the same connections between the frontal cortex of the brain and the visual processing area. This suggests that the ADHD brain processes information differently than anon-ADHD brain.

Brain Chemistry

The brain is a busy communication network where messages are relayed from one neuron (brain cell) to the next. There is a gap between neurons, which is called a synapse. In order for the message to be passed along, the synapse needs to be filled with a neurotransmitter. Neurotransmitters are chemical messengers, and each one is responsible for different functions.

The key neurotransmitters for ADHD are dopamine and noradrenaline.In the ADHD brain, there is dysregulation of thedopamine system. For example, there iseither too little dopamine, not enough receptors for it, or the dopamine is not being used efficiently.

Stimulant medications help ADHD because they encourage more dopamine to be produced or keep dopamine in the synapses longer.

The Relationship Between Dopamine and ADHD

Diagnosis

Brain scans cannot be used to diagnose ADHD. There is no objective test to diagnose ADHD. The diagnosis of ADHD requires a full evaluation by a qualified doctor, psychologist, or psychiatrist.Diagnosis includes:

  • An in-depth interview with the patient
  • A review of school reports and medical history
  • Tests to measure attention, distractibility, and memory.

With that information, the clinician can determine if the diagnostic guideline for ADHD set by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR) is met.

While PET and fMRI scans can be useful for research, they really only give an insight into how the brain is functioning at the moment the test was performed. Brain scans do not take into account how the brain operates in different situations, in the way a clinical test can during a detailed interview.

In addition,the scan data that has been studied is generally based on group averages, and may not apply to any particular individual. Theresults have not been normed, which is when large quantities of data are gathered and compared.

ADHD Symptom Spotlight: Brain Fog

7 Sources

Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

  1. American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders.5th ed. Washington, DC; 2013.

  2. Mueller AK, Fuermaier AB, Koerts J, Tucha L. Stigma in attention deficit hyperactivity disorder.Atten Defic Hyperact Disord. 2012;4(3):101-114. doi:10.1007/s12402-012-0085-3

  3. Hoogman M, Bralten J, Hibar DP, et al. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis.Lancet Psychiatry. 2017;4(4):310-319. doi:10.1016/S2215-0366(17)30049-4

  4. Kim BN, Kim JW, Kang H, et al. Regional differences in cerebral perfusion associated with the alpha-2A-adrenergic receptor genotypes in attention deficit hyperactivity disorder.J Psychiatry Neurosci. 2010;35(5):330-336. doi:10.1503/jpn.090168

  5. Sörös P, Hoxhaj E, Borel P, et al. Hyperactivity/restlessness is associated with increased functional connectivity in adults with ADHD: a dimensional analysis of resting state fMRI.BMC Psychiatry. 2019;19(1):43. doi:10.1186/s12888-019-2031-9

  6. Mazaheri A, Coffey-corina S, Mangun GR, Bekker EM, Berry AS, Corbett BA. Functional disconnection of frontal cortex and visual cortex in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2010;67(7):617-23. doi:10.1016/j.biopsych.2009.11.022

  7. Del Campo N, Chamberlain SR, Sahakian BJ, Robbins TW. The Roles of Dopamine and Noradrenaline in the Pathophysiology and Treatment of Attention-Deficit/Hyperactivity Disorder. Biol Psychiatry. 2011;69(12):e145-157. doi:10.1016/j.biopsych.2011.02.036

By Jacqueline Sinfield
Jacqueline Sinfield is an ADHD coach, and the author of "Untapped Brilliance, How to Reach Your Full Potential As An Adult With ADHD."

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How the ADHD Brain Biologically Differs From the Non-ADHD Brain (2024)

FAQs

How the ADHD Brain Biologically Differs From the Non-ADHD Brain? ›

In sum. The ADHD brain is smaller than the non-ADHD brain and has fewer connections between different brain regions. Their brains do not have the neural organization to self-regulate and to stop automatic responses.

How is the ADHD brain different from the non ADHD brain? ›

Research suggests that the ADHD brain differs from neurotypical brains in a number of ways, including the smaller size of certain brain structures (primarily while kids are still maturing), the level of activity in different areas, and how efficiently key neurochemicals, such as dopamine, are produced and transmitted.

How does a brain scan of ADHD differ from a normal brain? ›

Research shows that individuals diagnosed with ADHD have altered brain structures compared to those without ADHD. The brain of a child with ADHD matures more slowly, and certain areas such as the prefrontal cortex, cerebellum, hippocampus and amygdala are smaller in volume than that of typically developing children.

How does the ADHD brain differ from the normal brain motivation? ›

Via the transmission of dopamine, this pathway helps the prefrontal cortex facilitate executive functions such as cognition, working memory, and decision-making. In children with ADHD, these two pathways are thought to be disrupted, which can lead to impairment of cognitive and motivational functioning.

How does ADHD work biologically? ›

ADHD seems to involve impaired neurotransmitter activity in four functional regions of the brain: Frontal cortex. This region orchestrates high-level functioning: maintaining attention, organization, and executive function.

How do ADHD brains think differently? ›

The brain networks of people with ADHD may take more time to develop and be less effective at relaying certain messages, behaviors, or information. These brain networks may function differently in areas such as focus, movement, and reward.

How is ADHD brain different from a neurotypical brain? ›

It is in the prefrontal cortex that we problem-solve, make decisions, control impulses, and utilise logic. Motivation resides here. What is different in ADHD: The parts of the prefrontal cortex that manage attention and executive function are thinner in ADHD brains than they are in neurotypical brains.

Do ADHD brains work faster? ›

Shankman: Simply put, ADHD is the brain's inability to produce as much dopamine, serotonin, and adrenaline as “regular” people's brains produce. Because of that, our brains have become “faster.” When managed right, that becomes a superpower. Have you found that you tend to think faster than most people? Yes.

What is ring of fire ADHD? ›

Ring of Fire ADD is a proposed subtype of ADHD characterized by a distinctive “ring of fire” pattern of increased brain activity seen on SPECT scans. Single-photon emission computed tomography (SPECT) imaging is a type of imaging test used to identify variations in brain activity and blood flow.

Can ADHD show up on a brain scan? ›

Brain MRI is a new and experimental tool in the world of ADHD research. Though brain scans cannot yet reliably diagnose ADHD, some scientists are using them to identify environmental and prenatal factors that affect symptoms, and to better understand how stimulant medications trigger symptom control vs. side effects.

Do people with ADHD physically age slower? ›

ADHD and growing older more rapidly

Not managing or poorly managing these conditions contributes to faster biological aging. There is also the factor of stress in one's life. Higher amounts of stress cause the body to release hormones that remain at levels high enough to cause damage to one's body.

Is ADHD like having erectile dysfunction? ›

' It hinders the mind's natural ability to focus, sustain attention, and follow through with tasks, disrupting mental processes in a way analogous to how erectile dysfunction disrupts physical processes.

Do ADHD brains need more dopamine? ›

ADHD may indicate a dopamine deficiency or difficulties with processing dopamine in the brain. This can affect the ability to feel motivated or to find certain activities rewarding. Standard ADHD treatments, including medication, can help increase dopamine and improve symptoms.

What is the root cause of ADHD? ›

The cause(s) and risk factors for ADHD are unknown, but current research shows that genetics plays an important role. Recent studies link genetic factors with ADHD. In addition to genetics, scientists are studying other possible causes and risk factors including: Brain injury.

What chemicals do ADHD brains lack? ›

Since the two go hand-in-hand, experts believe that lower levels of dopamine and norepinephrine are both linked to ADHD. An imbalance in the transmission of dopamine in the brain may be associated with symptoms of ADHD, including inattention and impulsivity.

Are you born with ADHD or is it learned? ›

There's not one single cause of ADHD (attention-deficit/hyperactivity disorder) but studies have shown that the condition does run in families and that genetics play a major role.

What is the difference between a Neurodivergent brain and a normal brain? ›

While everyone's brain develops similarly, no two brains function just alike. Being neurodivergent means having a brain that works differently from the average or “neurotypical” person. This may be differences in social preferences, ways of learning, ways of communicating and/or ways of perceiving the environment.

What brain type do ADHD people have? ›

The affected brain areas are the prefrontal cortex and cerebellum, which control executive functions of concentration, attention span, judgment, organization, planning and impulse control; the anterior cingulate, which helps the brain shift gears and detect errors; the temporal lobes, which involve memory, learning, ...

Do ADHD brains have less dopamine? ›

Research has shown that people with ADHD tend to have low levels of dopamine in the brain. However, it is a complex condition that involves dysregulation of dopamine and another chemical, norepinephrine. Stimulant medications that treat ADHD can prevent the reuptake of dopamine, increasing brain levels of the chemical.

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